Anemia, Iron Overload, and Oxidant/Antioxidant Status in β-Thalassemia - Paperbackby Muhtada Ali Challoob (Author), Adel Kareem Jasim (Author) Thalassemia is a hereditary hemolytic anemia caused by mutations in globin genes that cause reduced or complete absence of specific globin chains (commonly, or ). Although oxidative stress is not the primary etiology of thalassemia, it mediates several of its pathologies. The main causes of oxidative stress in thalassemia are the degradation of the unstable hemoglobin and iron overload both